For once in their lives, Tom and Jerry are on the same team. Instead of playing games of cat and mouse in Tom and Jerry: Frantic Antics!, they are working toward the same goal: to rescue their friend Robyn Starling's father, all they while battling Aunty Figg and her dangerous henchmen. Also, Tom and Jerry's house has recently been mysteriously destroyed, so they must set out to figure out what happened.

Throughout the game, you will play as either Tom or Jerry, depending on which level you are in. In the two-player mode, Tom and Jerry will be on the screen at the same time. Both characters can walk, run, jump, duck, roll over enemies, climb ladders, and throw weapons, such as ink, water, and footballs. Fish, cheese, and cookies can be picked up to gain bonus lives and restore health.

There are eight locations which you must get through in Tom and Jerry: Frantic
Antics!. On The Street, you must avoid or battle cars, rats, an old lady, and squirting fire hydrants. In the Living Room, you must get out of the house as fast as you can while dealing with a swinging wrecking ball, wacky birds, and falling vases. In The Alley, where you will meet Robyn Starling, you must avoid flying trash can lids, deadly seaweed, mouse-eating fish, and an octopus, all the while gather as much cheese as you can. In The Library, you must search for a missing telegram while fending off the rotten rat pack and avoiding falling chandeliers.

The Basement is filled with evil dogs (which you must set free by finding the right control panel) and electrical outlets. Up in The Attic, you must find Robyn's backpack, crawl up and down numerous ladders, use a train to cross electrical tracks, and be careful of the rat pack. At The Carnival, you must watch out for octopuses and piranha while underwater. While above ground (sometimes riding in balloons), you must steer clear of ping pong ball-spitting clowns, a bumper car, monkeys throwing pinwheels, and, of course, the rat pack.

In the last level, The Cabin, you will eventually face Aunty Figg. Here you must
capture fish and drink lots of water to put out raging fires, all the while avoiding burning logs and falling lanterns. If you reach the end of the game, you will have successfully reunited Robyn with her beloved father.

Tom and Jerry: Frantic Antics (Sega Genesis, 1993)